Comparison of Design Strategies for Promotion of β-Peptide 14-Helix Stability in Water
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چکیده
منابع مشابه
Helix macrodipole control of beta 3 peptide 14-helix stability in water.
beta-Peptides have attracted considerable attention by virtue of their ability to populate helical secondary structures in methanol, even in the absence of stabilizing tertiary interactions. Recent efforts in beta-peptide design have produced few beta3-peptides that form stable 14-helices in water; those that do require stabilizing intramolecular salt bridges on two of three helical faces and t...
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ژورنال
عنوان ژورنال: ChemBioChem
سال: 2008
ISSN: 1439-4227,1439-7633
DOI: 10.1002/cbic.200800355